Rosuvastatin attenuates piroxicam-mediated gastric ulceration and hepato-renal toxicity in rats
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چکیده
منابع مشابه
Khaya senegalensis inhibits piroxicam mediated gastro-toxicity in wistar rats
Objective:The purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of Khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in Wistar rats. Materials and Methods: Thirty healthy male and female Albino Wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: Normal saline, piroxi...
متن کاملkhaya senegalensis inhibits piroxicam mediated gastro-toxicity in wistar rats
objective:the purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in wistar rats. materials and methods: thirty healthy male and female albino wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: normal saline, piroxi...
متن کاملHistopathological and Molecular Studies on Tramadol Mediated Hepato-Renal Toxicity in Rats
Tramadol, a broadly used opioid in recent years, is an effective analgesic agent for the treatment of moderately severe acute or chronic pain. The liver and kidneys are responsible for the metabolism and excretion of opioids, which may cause hepatotoxicity and nephrotoxicity. The present study was designed to evaluate the toxic effects of tramadol on the liver and kidney of experimental rats. T...
متن کاملKhaya senegalensis inhibits piroxicam mediated gastro-toxicity in wistar rats
OBJECTIVE The purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of Khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in Wistar rats. MATERIALS AND METHODS Thirty healthy male and female Albino Wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: Normal saline, pirox...
متن کاملEffects of Nigella sativa oil and ascorbic acid against oxytetracycline-induced hepato-renal toxicity in rabbits
Objective(s): Oxytetracycline (OTC) is a broad spectrum antibiotic widely used for treatment of a wide range of infections. However, its improper human and animal use leads to toxic effects, including hepatonephrotoxicity. Our objective was to evaluate protective effects of Nigella sativa oil (NSO) and/or ascorbic acid (AA), against OTC-induced hepatonephrotoxicity in rabbits. Materials and Me...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2019
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2018.11.004